However, the package labeling for promethazine states that antihistamines are contraindicated for use in the specific treatment of lower respiratory tract symptoms including asthma and should be avoided in patients with significant respiratory depression, including COPD and sleep apnea. Promethazine hydrochloride should not be used in pediatric patients less than 2 years old because of the potential for fatal respiratory depression. Too much dreaming is the side effect. Pre- and Postoperative Use - Promethazine HCl in 12.5 to 25 mg doses for children and 50 mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep. Share. My Gp told me about Phenergan. This is a reivew of how effective Promethazine hydrochloride (promethazine hydrochloride) is for Insomnia and for what kind of people. Data sources include IBM Watson Micromedex (updated 3 May 2021), Cerner Multum™ (updated 4 May 2021), … Promethazine Hydrochloride Sometimes I still feel a bit drowsy in the mornings and have discovered I only need the lowest dose to get a good night's sleep. It has been popular in the past as a means of 'settling' children, but promethazine should not be used in this way. I only take it the night following a sleepless night . It also reduces motion sickness and has antiemetic (via its action on the dopamine receptor D 2) and anticholinergic properties.In some countries it is prescribed for insomnia when benzodiazepines are contraindicated. Phenergan (promethazine) for Sedation: “I suffer PMS and insomnia. Promethazine hydrochloride (0.125, 0.25, 0.5, 1.0, and 2.0 mg/kg, sc) increased TST and NREM minutes (especially slow-wave sleep) in a dose-response relationship. It may be taken (for a few days only) to help promote sleep in adults with sleeping problems. Promethazine also makes you feel sleepy (has a sedative effect). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Original Poster 2 years ago. Report Save. level 2. 1. Minutes of REM were decreased at the highest dose. Avoid concomitant use of other drugs with respiratory depressant effects. The study is created by eHealthMe from 7 Promethazine hydrochloride users and is updated continuously. Promethazine is effective against sleep allergies and nausea, but as said before, you wake up sleepy. Promethazine hydrochloride in 12.5- to 25-mg doses for children and 50-mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep. Percentage REM sleep decreased at the three highest doses. 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